In-silico molecular modelling, MM/GBSA binding free energy and molecular dynamics simulation study of novel pyrido fused imidazo[4,5-c]quinolines as potential anti-tumor agents

With an alarming increase in the number of cancer patients and a variety of tumors, it is high time for intensive investigation on more efficient and potent anti-tumor agents.Though numerous agents have enriched the literature, still there exist challenges, with the availability of different targets and possible cross-reactivity.Herein we have chos

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SAliBASE: A Database of Simulated Protein Alignments

Simulated Quartz Accessories alignments are alternatives to manually constructed multiple sequence alignments for evaluating performance of multiple sequence alignment tools.The importance of simulated sequences is recognized because their true evolutionary history is known, which is very helpful for reconstructing accurate phylogenetic trees and a

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